The Roche Cobas c 503 Chemistry Analyzer, provided by Roche Diagnostics
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Package Size: EA
Refurbished Roche cobas pro c503 Chemistry Analyzer
The chemistry unit of Roche's current cobas pro platform, rebuilt Down-To-Frame® to original specification. You save up to 70% compared with buying new, and you can finance with $0 down.
The Roche cobas c503 runs up to 1,000 photometric tests an hour on cobas pro integrated solutions, with 60 reagent positions, automatic calibration and no daily maintenance. Buy it refurbished from Diamond keep more budget for other priorities.
check_circleSave up to 70% compared with a new cobas pro c503, on Roche's newest chemistry platform.
check_circleSkip daily maintenance on the c503: SonicWash cleans the sample probes, so your staff start the day running samples.
check_circleKeep reagents on board for up to 6 months with cobas c pack green, which cuts waste on low-volume tests.
check_circleLet cobas AutoCal handle calibration scheduling instead of a tech.
check_circleFinance up to $2 million with $0 down, and roll shipping into the payments.
check_circleEvery unit is rebuilt Down-To-Frame® by an FDA-registered, ISO 13485:2016 certified refurbisher, installed by our engineers and eligible for our service plans.
How the cobas pro c503 runs your chemistry
The c503 is the mid-volume chemistry unit of cobas pro integrated solutions. A sample supply unit loads and routes racks, an ISE unit runs electrolytes, and the c503 runs photometric chemistry. An e 801 immunoassay unit can join the same line.
Less hands-on time
biotechNo daily maintenance on the c503. cobas SonicWash cleans the sample probe ultrasonically. Roche states it eliminates daily maintenance on the c503 and reduces clot events.
check_circleCalibration on autopilot. cobas AutoCal schedules and runs calibrations, so a tech isn't tracking calibration due dates by hand.
check_circleBackground maintenance. The system runs its routine maintenance tasks in the background instead of holding up the morning start.
Reagents
science60 reagent positions. Enough for most mid-volume menus to stay on board.
check_circlecobas c pack green. Roche's newer packs hold more tests and stay stable on board for up to 6 months, depending on the assay. Low-volume tests stop expiring before you finish the pack.
scienceLoad without stopping. The reagent manager takes packs during operation and standby, and RFID tags register each pack automatically.
Samples and result integrity
biotechSample supply unit. Up to 300 samples load and 300 unload directly, at up to 1,000 samples an hour, or the line connects to lab automation.
check_circle1 to 25 µL per test, with a dedicated probe for whole-blood HbA1c.
biotechBroad sample types. Serum, plasma, urine, CSF, whole blood and hemolysate for HbA1c, plus oral fluid, amniotic fluid and processed stool.
biotechSerum indices, clot and liquid level detection, ultrasonic mixing. The c503 checks every sample for interference and clots, with no stirrer touching the reaction.
check_circleResults in 3 to 10 minutes for chemistry tests, from sampling to result.
The cobas pro test menu
Roche lists more than 110 clinical chemistry parameters for the c503, and the full cobas pro line adds electrolytes on the ISE unit and immunoassays on the e 801.
cobas c503Substrates, enzymes, lipids, specific proteins, therapeutic drug monitoring, drugs of abuse, whole-blood HbA1c
ISE unitSodium, potassium, chloride
cobas e 801 (optional)Thyroid, cardiac, fertility, tumor markers, anemia, bone, infectious disease and other immunoassays
The c503 runs cobas c pack green reagents, Roche's newer reagent generation, which are different packs from the cobas c packs used on the cobas 6000 and cobas 8000. Send your menu with your quote request and we'll confirm what runs on the unit you're buying.
Cobas pro vs Cobas 8000. Which Roche platform fits your lab?
Both are Roche serum work area systems for mid- to high-volume labs. The cobas 8000 reached the US market in 2010, and cobas pro followed in 2019.
sciencePeak capacity. A cobas 8000 configuration reaches up to 9,800 tests an hour with up to 280 reagent channels. cobas pro offers up to 242 reagent positions on a single line, with the c703 unit for high-volume chemistry. For the very largest workloads, the cobas 8000 scales further.
check_circleDaily maintenance. On cobas pro, SonicWash removes daily maintenance from the c503, and other maintenance runs in the background. A cobas 8000 keeps a daily maintenance routine on its modules.
scienceReagents. cobas pro runs cobas c pack green, with up to 6 months on-board stability and RFID tracking. A cobas 8000 runs cobas c packs. The two are different reagent lines, so check your reagent agreement before switching platforms.
check_circleCalibration. cobas pro adds cobas AutoCal for automated calibration.
paymentsCost. The cobas 8000 is the older platform. Ask us to quote both, and compare the refurbished price against the labor cobas pro saves on maintenance and calibration.
cobas procobas 8000
US introduction20192010
Mid-volume chemistry unitc503, 1,000 tests/hour, 60 positionsc502, 600 tests/hour, 60 channels
High-volume chemistry unitc703, 2,000 tests/hour, 70 positionsc701 or c702, 2,000 tests/hour, 70 channels
Reagent capacityUp to 242 positions on a single lineUp to 280 channels per configuration
Reagentscobas c pack green, up to 6 months on board, RFIDcobas c packs
Daily maintenance on chemistryNone on the c503 (SonicWash)Conventional routine
Calibrationcobas AutoCalNo AutoCal
Cobas pro configurations with the c503
biotechSample supply unit + ISE + c503. A chemistry and electrolyte line for a mid-volume lab, at up to 1,900 tests an hour combined.
priority_highSample supply unit + ISE + c503 + e 801. Chemistry, electrolytes and immunoassays from one rack, with STAT immunoassays in 9 minutes on the e 801.
check_circleLines with a c703. High-volume labs pair the c703 for routine chemistry with a c503 for specialty tests and backup.
Planning your site for a Cobas pro c503
biotechFloor space. The c503 with its sample buffer measures 150 x 114 x 135 cm (59.1 x 44.9 x 53.3 in, W x D x H). The sample supply unit adds 132 cm (52 in) of width and the ISE unit 45 cm (17.7 in).
local_shippingFloor load. The c503 weighs 790 kg (1,742 lb), the sample supply unit 250 kg (551 lb) and the ISE unit 170 kg (375 lb). Check floor ratings along the delivery path.
electrical_servicesPower. Single-phase 200 to 240 V at 50 or 60 Hz. The c503 draws under 2.4 kVA, and a full line with an e 801 stays at or under 5.5 kVA.
water_dropDeionized water. The c503 uses about 32 L an hour on average, so size your water system for it, plus the other units on the line.
thermostatRoom conditions. 18 to 32 °C, 30 to 85% relative humidity, non-condensing, at up to 2,000 m altitude. Noise stays under 65 dBA running and 56 dBA in standby.
UnitDimensions (W x D x H)WeightPowerDI water
cobas c503 with sample buffer150 x 114 x 135 cm (59.1 x 44.9 x 53.3 in)790 kg (1,742 lb)Under 2.4 kVAAbout 32 L/hour
Sample supply unit with monitor132 x 119 x 143 cm (52.0 x 46.7 x 56.3 in)250 kg (551 lb)Under 0.8 kVA with sample buffersNot applicable
ISE unit45 x 115 x 116 cm (17.7 x 45.3 x 45.7 in)170 kg (375 lb)Under 0.4 kVAUnder 2 L/hour
cobas c503, c501, c502 or cobas pure c303?
check_circleChoose the cobas pro c503 if you want Roche's current mid-volume chemistry unit, with no daily maintenance, automated calibration and 6-month reagent stability.
check_circleChoose the cobas c501 if the same 1,000 tests an hour on the older cobas 6000 platform, with ISE built into the module, fits your budget better.
check_circleChoose the cobas c502 if you already run a cobas 8000 and need a mid-volume chemistry module for it.
check_circleChoose the cobas pure c303 if your volume is lower and you want the same c pack green reagents and cobas pro-style operation on a smaller footprint.
Who uses a refurbished Roche cobas pro c503?
speedHospitals replacing a cobas 6000. The c503 matches the c501's 1,000 tests an hour and adds no-daily-maintenance operation and automated calibration.
check_circleLabs short on staff. Removing daily maintenance and manual calibration scheduling gives techs back time at the start of every shift.
check_circleLabs already running cobas pro or cobas pure. A refurbished c503 adds capacity or backup on the same c pack green reagents.
check_circleHigh-volume labs with a c703. A c503 takes specialty tests and keeps chemistry running during c703 maintenance.
check_circleBudget-bound labs that want Roche's current platform. Refurbished pricing puts cobas pro within reach of labs that would otherwise stay on an older system.
cobas pro c503 price and what shapes your quote
A refurbished cobas pro c503 from Diamond Diagnostics costs up to 70% less than a new one. We don’t publish a set price because your cost is impacted by…
biotechThe rest of the line. Whether you need the sample supply unit and ISE unit with the c503, or you're adding it to a cobas pro you already own.
paymentsBuild year and software version. Newer units and current software cost more.
check_circleImmunoassay. Adding an e 801 to the same line.
engineeringInstall and verification. Setup, assay verification and staff training at your site.
check_circleService coverage. The plan you choose, from Platinum to per-visit.
swap_horizTrade-in credit. The value of the analyzer you're retiring.
Financing a cobas pro
Finance or lease up to $2 million, with application-only approval up to $400,000.
Start at $0 down with a low introductory payment.
Get a fast credit decision and terms built around your budget.
Roll shipping and other costs into the same payments.
Send your volume, menu and current analyzer for a quote on a cobas pro line built around the c503.
Why buy your refurbished cobas pro c503 from Diamond
Rebuilt to the frame, even on a newer platform
A used c503 may be only a few years old, but it can still come with a worn sample probe, reagent manager faults or an unknown service history. We rebuild every c503 to the frame, replace wear parts with new probes, syringes, seals, tubing and reagent lines, and validate it with multi-level QC before it's crated. We are FDA registered and ISO 9001:2015 and ISO 13485:2016 certified in the US and the EU.
Installed, verified and serviced by our engineers
Our engineers install the c503 on your cobas pro line, verify your assays and train your staff.
Every unit is eligible for our field service plans, from Platinum with next-day response to per-visit support.
Preventive maintenance plans keep it on schedule at a fixed cost.
Trade in your current analyzer
Diamond may accept your old analyzer in trade, handle the deinstall and decontamination, and put its value toward your c503.
Roche cobas pro c503 FAQ
Q: What is the throughput of the cobas pro c503?A: Up to 1,000 photometric tests an hour, with chemistry results in 3 to 10 minutes.
Q: How many reagent positions does the cobas c503 have?A: 60, loaded automatically during operation and standby.
Q: Does the cobas c503 need daily maintenance?A: Roche states cobas SonicWash eliminates daily maintenance on the c503.
Q: Does the cobas c503 run electrolytes?A: No. On cobas pro, sodium, potassium and chloride run on a separate ISE unit next to the c503.
Q: What's the difference between cobas pro and cobas 8000?A: cobas pro is Roche's newer platform, with c pack green reagents, automated calibration and no daily maintenance on the c503. The cobas 8000 is the older platform and scales to more tests an hour on its largest configurations.
Q: Can the cobas c503 run whole-blood HbA1c?A: Yes, with a dedicated sample probe for whole blood.


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95 Total Assays Tested
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| Manufacturer: | Roche Diagnostics (Hoffmann) |
| Series: | Cobas |
| Sample Types: | CSF, Hemolysate, Plasma, Serum, Urine, Whole Blood |
| Maximum Throughput: | 1000 tests/hour |
| Sample Size Min: | 1 μL |
| Direct Sample (STAT): | Yes |
| Auto Sample Handling: | Yes |
| Sample Input Type: | Sample Tube |
| Reagent Type: | Automatic w/Level Sensing |
| Reagent System: | Closed |
| Reagent Capacity: | 60 |
| On-Board Refrigeration: | Yes |
| Configuration: | Floor Model |
| Height: | 136 cm (53 in) |
| Width: | 150 cm (59 in) |
| Depth: | 114 cm (45 in) |
| Weight: | 740 kg (1628 lb) |
| Water Requirement: | No |
| Power Supply: | 220V |
| Point Of Care: | No |
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